{"id":11214,"date":"2017-09-20T00:00:00","date_gmt":"2017-09-20T00:00:00","guid":{"rendered":"https:\/\/www.cancerresearch.org\/media-room\/the-cancer-research-institute-and-parker-institute-for-cancer-immunotherapy-announce-first-patients-treated-in-pancreatic-cancer-clinical-trial-combining-immunotherapy-and-chemotherapy\/"},"modified":"2022-07-13T04:18:24","modified_gmt":"2022-07-13T04:18:24","slug":"parker-institute-cri-pancreatic-clinical-trial","status":"publish","type":"cri_news","link":"https:\/\/www.cancerresearch.org\/es\/media-room\/parker-institute-cri-pancreatic-clinical-trial","title":{"rendered":"The Cancer Research Institute and Parker Institute for Cancer Immunotherapy Announce First Patients Treated in Pancreatic Cancer Clinical Trial Combining Immunotherapy and Chemotherapy"},"content":{"rendered":"\n

The Parker Institute for Cancer Immunotherapy<\/a> and the Cancer Research Institute<\/a> (CRI) today announced the first patients have begun treatment in a new pancreatic cancer multi-center clinical trial. To combat the nation\u2019s third deadliest cancer, the phase 1b\/2 open-label study will explore the combination of standard chemotherapy and two immunotherapy agents: an anti-PD-1 checkpoint inhibitor and a novel antibody targeting CD40, a protein that when activated can drive the immune system to attack tumors.<\/p>\n\n\n\n

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To bring this project to life, the Parker Institute and Cancer Research Institute have joined forces to collaborate with industry partner Bristol-Myers Squibb Company<\/a> (BMS) and biotech company Apexigen<\/a>, Inc. The research will be conducted across the Parker Institute\u2019s network of leading cancer research centers, led by the Abramson Cancer Center of the University of Pennsylvania. The trial is expected to open imminently at Memorial Sloan Kettering Cancer Center, followed by additional Parker Institute sites, including Stanford Medicine, the University of California, Los Angeles, the University of California, San Francisco and The University of Texas MD Anderson Cancer Center.<\/p>\n\n\n\n

Leveraging the Parker Institute\u2019s unique collaborative model, the project not only unites the world\u2019s best researchers in industry and academia but exemplifies the institute\u2019s ability to develop faster and more efficient clinical studies. The Parker Institute\u2019s single IRB reliance agreement eliminates the need for multiple review boards that can cause trial delays. In fact, the study opened just months after the clinical trial collaboration agreement was signed by the Parker Institute, CRI, and BMS in late March<\/a>.<\/p>\n\n\n\n

\u201cA trial of this magnitude has many moving parts: multiple contracts and co-funders, a four-drug IND, a major industry partner, a biotech firm, and six university hospitals,\u201d said Ramy Ibrahim, MD, vice president of clinical development at the Parker Institute for Cancer Immunotherapy. \u201cLeveraging the Parker Institute\u2019s infrastructure, we streamlined the process and successfully launched the trial in less than six months, perhaps half the time it would have taken otherwise.\u201d<\/p>\n\n\n\n

The study begins as deaths from pancreatic cancer are on the rise. Pancreatic cancer is now the third leading cause of cancer-related deaths<\/a> in the nation, surpassing breast cancer, according to 2017 estimates from the National Cancer Institute. The deadly disease will kill more than 43,000 people in the United States<\/a> this year.<\/p>\n\n\n\n

Patients are often diagnosed in the late stages of disease and have few treatment options. However, preclinical data suggest that the proposed combination warrants further study.<\/p>\n\n\n\n

\u201cWe think this clinical trial offers great hope based on what we have observed in prior studies,\u201d said the study\u2019s lead investigator, Robert Vonderheide, MD, DPhil, director of the Abramson Cancer Center of the University of Pennsylvania. An expert in pancreatic cancer, the CD40 pathway, and immunotherapy, Dr. Vonderheide designed the study. \u201cWe have wanted to do this trial for many years. We\u2019re finally able to initiate it thanks to support from the Parker Institute and Cancer Research Institute for a boundary-pushing collaborative model and their ability to rapidly bring together the right team.\u201d  <\/p>\n\n\n\n

In phase 1, investigators will evaluate the safety of the combined treatments. Each patient will receive gemcitabine and nab-paclitaxel, two chemotherapy drugs that are standard of care. Those will be tested in combinations with Apexigen\u2019s APX005M, a novel monoclonal antibody that targets CD40, and Bristol-Myers Squibb\u2019s anti-PD-1 checkpoint inhibitor nivolumab. Another cohort will receive all four drugs. For additional information on this trial (NCT03214250), please visit www.clinicaltrials.gov<\/a>.<\/p>\n\n\n\n

\u201cWe are excited to be a part of this important new initiative to develop novel treatment options for patients,\u201d said Ovid Trifan, MD, PhD, chief medical officer of Apexigen, Inc. \u201cAPX005M is a potential best-in-class CD40 agonist that works by activating the immune system\u2019s antigen-presenting cells in the tumor microenvironment. Preclinical data strongly demonstrated that this combination provides robust and synergistic anti-tumor efficacy.\u201d<\/p>\n\n\n\n

\u201cEnabling and empowering global experts to drive disruptive innovation is central to our mission at CRI,\u201d said Aiman Shalabi, Pharm.D., MBA, Cancer Research Institute Chief Medical Officer. \u201cI am excited to see how such collaboration can bring strong science to pancreatic cancer patients, who desperately need new options.\u201d <\/p>\n\n\n\n

\u201cBristol-Myers Squibb is thrilled to be part of an innovative research model where each partner acts with urgency to advance potential new treatments for patients facing deadly cancers,\u201d said Awny Farajallah, MD, vice president, head of U.S. Medical Oncology at Bristol-Myers Squibb. \u201cWe believe in the promise of combination therapy and are eager to learn more from this study evaluating potential synergies between our I-O medicine and other mechanisms of action.<\/p>\n\n\n\n\n\n

About the Cancer Research Institute <\/strong>
The Cancer Research Institute (CRI), established in 1953, is the world\u2019s leading nonprofit organization dedicated exclusively to immuno-oncology, also called cancer immunotherapy. CRI has invested over $344 million to support research conducted by a global network of immunologists and clinical experts at the world\u2019s leading medical centers and universities. CRI\u2019s clinical program, The Anna-Maria Kellen Clinical Accelerator<\/a>, is a unique academia-industry collaboration model that serves as an \u201cincubator\u201d for promising new immunotherapy combinations. CRI\u2019s venture philanthropy fund supports clinical trials within this program, which fosters a collaborative environment that enables scientists to advance their most ambitious clinical and translational research ideas, and accelerates studies that one group or company could not do alone. To learn more, go to www.cancerresearch.org<\/a>.<\/p>\n\n\n\n

About the Parker Institute for Cancer Immunotherapy<\/strong>
The Parker Institute for Cancer Immunotherapy<\/a> brings together the best scientists, clinicians and industry partners to build a smarter and more coordinated cancer immunotherapy research effort. The Parker Institute is an unprecedented collaboration between the country\u2019s leading immunologists and cancer centers, including Memorial Sloan Kettering Cancer Center, Stanford Medicine, the University of California, Los Angeles, the University of California, San Francisco, the University of Pennsylvania and The University of Texas MD Anderson Cancer Center. The Parker Institute network also includes more than 40 industry and nonprofit partners, more than 60 labs and more than 300 of the nation\u2019s top researchers focused on treating the deadliest cancers. The goal is to accelerate the development of breakthrough immune therapies capable of turning most cancers into curable diseases. The institute was created through a $250 million grant from The Parker Foundation.<\/p>\n\n\n\n

About Bristol-Myers Squibb<\/strong>
Bristol-Myers Squibb is a global biopharmaceutical company whose mission is to discover, develop and deliver innovative medicines that help patients prevail over serious diseases. For more information about Bristol-Myers Squibb, visit us at BMS.com or follow us on LinkedIn, Twitter, YouTube and Facebook.<\/p>\n\n\n\n

About Apexigen, Inc.<\/strong>
Apexigen is a clinical-stage biopharmaceutical company discovering and developing a new generation of antibody therapeutics for oncology, with an emphasis on new immuno-oncology agents that could harness the patient\u2019s immune system to combat and eradicate cancer. APX005M and the Company\u2019s additional preclinical programs were discovered using APXiMABTM<\/sup>, Apexigen\u2019s proprietary product discovery platform. This platform has enabled the Company and its collaboration partners to discover and develop high-quality therapeutic antibodies against a variety of molecular targets, including targets that are difficult to drug with conventional antibody technologies. Seven product candidates discovered using APXiMABTM<\/sup> are currently in clinical development, either internally by Apexigen or by its partners. For more information, please visit www.apexigen.com<\/a>.<\/p>\n\n\n\n

Contact Information:<\/strong><\/p>\n\n\n\n

Cancer Research Institute: Brian Brewer, bbrewer@cancerresearch.org<\/a>, 212-688-7515, x242<\/p>\n\n\n\n

Parker Institute for Cancer Immunotherapy: Shirley Dang, sdang@parkerici.org<\/a>, 415-930-4385<\/p>\n\n\n\n

Bristol-Myers Squibb: Laurel Sacks, laurel.sacks@bms.com<\/a>, 609-302-5456<\/p>\n\n\n\n

Apexigen, Inc.: Mark Nevins, mnevins@apexigen.com<\/a>, 650-931-6236<\/p>\n","protected":false},"excerpt":{"rendered":"

Cancer Research Institute collaboration with the Parker Institute for Cancer Immunotherapy, Bristol-Myers Squibb, and Apexigen will test CD40 antibody APX005M, nivolumab, and chemotherapy in pancreatic cancer patients.<\/p>\n","protected":false},"featured_media":5354,"template":"","tags":[156,157,145,158,98,99],"resource_cancer_types":[],"resource_patient_age":[],"resource_cancer_stage":[],"resource_treatment_type":[],"resource_treatment_status":[],"class_list":["post-11214","cri_news","type-cri_news","status-publish","has-post-thumbnail","hentry","tag-apx005m","tag-chemotherapy","tag-clinical-trial","tag-nivolumab","tag-pancreatic-cancer","tag-partnerships"],"acf":[],"yoast_head":"\nThe Cancer Research Institute and Parker Institute for Cancer Immunotherapy Announce First Patients Treated in Pancreatic Cancer Clinical Trial Combining Immunotherapy and Chemotherapy - Cancer Research Institute<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.cancerresearch.org\/media-room\/parker-institute-cri-pancreatic-clinical-trial\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The Cancer Research Institute and Parker Institute for Cancer Immunotherapy Announce First Patients Treated in Pancreatic Cancer Clinical Trial Combining Immunotherapy and Chemotherapy - 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