Metastasis, the process by which cancer cells from one tumor migrate to a distant organ and form a secondary tumor there, causes about 90% of cancer-related deaths. Once a tumor has metastasized, a patient’s odds of survival worsen, so there is a huge need for strategies that can prevent metastasis as well as treat metastatic tumors once they’ve formed. To that end, Dr. Jain is examining how the abnormal blood vessels that supply tumors with nutrients may also enable metastasis. He’s examining if a drug that makes tumor vessels “normal” again can prevent breast cancer metastasis and if it improves the effectiveness of checkpoint inhibitors. This should improve our understanding of metastasis as well as help identify new approaches to prevent and treat it.
Projects and Grants
Improving immunotherapy for metastatic breast cancer via normalization of the tumor microenvironment
Massachusetts General Hospital | Leukemia | 2014
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