CRI Funded Scientists

Min-Hee Oh, PhD, Postdoctoral Fellow

Yale University

Area of Research: All Cancers

Immunotherapies that take advantage of our T cells have led to remarkable benefits in many types of advanced cancers. But they don’t work in many cases because tumors create hostile microenvironments that suppress T cells and keep them in a dysfunctional state. This includes a metabolic barrier that deprives T cells of essential nutrients, which Dr. Oh is now investigating.

In particular, she’s exploring how the lack of key nutrients required for tRNAs might impact T cells’ ability to produce proteins. She seeks to define how tRNAs are modified (and by what enzymes), and to determine how different metabolic environments affect tRNA modifications and protein production in T cells. Ultimately, her discoveries could reveal new targets to go after to improve the effectiveness of cancer immunotherapy.

Projects and Grants

Identifying the Role of tRNA Modifications in T Cells as a Translational Checkpoint in Metabolically Rewired Tumors

Yale University | All Cancers | 2021 | Richard, Flavell, PhD

This website uses tracking technologies, such as cookies, to provide a better user experience. If you continue to use this site, then you acknowledge our use of tracking technologies. For additional information, review our Privacy Policy.