CRI Funded Scientists

Elodie Segura, PhD, CLIP Investigator

Institut Curie

Responses to immunotherapies against cancers can be affected by multiple factors, including environmental signals. In particular, nutrition could represent an important player, as it can modulate the immune system through small molecules produced during digestion or by the intestinal flora. There is scientific evidence that dietary interventions could provide clinical benefit to patients being treated with checkpoint blockade therapy such as anti-PD1. However, our knowledge of the direct effects of dietary nutrients on anti-tumor immune responses is still limited. Dr. Segurais interested in a molecule called Aryl Hydrocarbon Receptor (AhR) recognizing products produced by the digestion of certain vegetables such as broccoli and cauliflower. Based on their previous work, they hypothesize that nutrients recognized by AhR play a role in immune responses against tumors. The specific aims of this project are to determine which immune cells are modulated by these nutirents and how their properties are affected during anti-PD1 treatment in mouse models. Dr. Segura’s results will allow a better understanding of the impact of food products on anti-tumor immune responses and will provide a proof-of-concept for dietary interventions to ameliorate the response of patients treated with checkpoint blockade therapy.

Projects and Grants

Deciphering the impact of dietary nutrients on anti-tumor immune responses in checkpoint blockade therapy

Institut Curie | All Cancers | 2022

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