T cell receptors (TCRs) allow T cells to interact with other immune cells and identify and target cancer cells. Upon activation, these TCRs can form giant clusters with other proteins in T cells. The effects of this clustering are unknown though, so Dr. Su established a system that models the TCR signaling pathway to investigate them. He’s found that the clusters enhance the activity of certain enzymes, which promote both T cell activation and T cells’ interactions with tumor cells. These insights may lead to the development of therapies that trigger these clusters to improve the anti-tumor ability of T cells.
University of California, San Francisco | All Cancers, Leukemia | 2014 | Ronald D. Vale, Ph.D.
*Immunotherapy results may vary from patient to patient.
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This Skin Cancer Awareness month, discover new research, treatments, and progress for a future immune to skin cancer.
Birdies & Brews mixes beer and golf while raising funds for cancer immunotherapy research.