Dying cancer cells often release DNA that can be recognized by the protein STING, which then stimulates interferon (IFN) production and an anti-tumor immune response. However, once STING is activated, how it mediates an immune response is still unclear, so Dr. Tan is investigating how a group of intracellular trafficking proteins regulate STING and anti-cancer responses. Specifically, he’s seeking to identify STING’s binding properties and how that regulates its activity, which could help foster STING-targeting strategies that improve outcomes in patients.
Projects and Grants
Phosphoinositide regulation of STING trafficking and cancer immunity
The University of Texas Southwestern Medical Center | All Cancers | 2016 | Zhijian J. Chen, Ph.D.
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