Different cues can determine whether pro-cancer or anti-cancer T cells develop. To improve our understanding of these developmental cues, Dr. Issuree is characterizing the roles of the Runx family of regulatory proteins. She has found that Runx1/3 proteins influence CD4 and CD8 T cell commitment through a process known as DNA methylation, which influences gene expression patterns. She’s currently investigating the mechanisms through which these proteins modulate DNA methylation to open potential new avenues for therapeutic targeting. Furthermore, she’s also discovered a role for Runx proteins in controlling Th17 T cell programs that can promote cancer. Moving forward, Dr. Issuree plans to uncover how Runx proteins regulate T cell commitment and function so that strategies can be designed to target this pathway and benefit patients.
I truly believe that the path to unlocking how the human body fails to keep cancer in check is via a thorough understanding of the basic immune checkpoints in place, and it is with this belief that I continue to dig deeper into molecular aspects of cell function with the instrumental support from the CRI.
Projects and Grants
Roles of Runx3 in inflammatory T cells and colorectal cancer
New York University Medical Center | Colorectal Cancer | 2015 | Dan R. Littman, M.D., Ph.D.
Let's spread the word about Immunotherapy! Click to share this page with your community.