Immune responses arise from complex interactions between different cell types, and it can be hard to tell which components cause which behaviors. Dr. Dingal wants to change that by making it easier to tease apart the many factors. To do that, he’s created a tool that enables desired genes to be turned on or off under precise conditions, and then he can see how those changes affect the activity of various cell-signaling pathways in addition to the overall cell behavior. With a better understanding of how specific genes contribute to certain behaviors, especially those involved in the interactions between cancer and the immune system, new targets or cell behaviors could potentially be exploited to make immunotherapy more effective.
CRI’s support to postdoc scientists outside of the immunology field is refreshing and forward-thinking. It fosters diverse ways of thinking and potentially valuable insights otherwise not possible.
Projects and Grants
Programmable cancer recognition using a chimeric system of Notch and CRISPR
Stanford University | All Cancers | 2015 | Lei S. Qi, Ph.D.
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