Neutrophils, eosinophils, basophils, and mast cells belong to an important class of innate immune cells known as granulocytes. These cells are recruited to sites of infection or injury, where they can help clear out dangerous invaders, stimulate inflammation, and aid immune responses. On their surfaces, granulocytes have numerous receptors called GPCRs, which control many immune cell behaviors, including cell migration.
Dr. De Giovanni is investigating a newly recognized GCPR—GPR35—that might be required by immune cells for efficient homing and migration. In particular, he seeks to understand how GPR35 and the molecules that bind it regulate the ability of granulocytes to be recruited and migrate to sites of injury and infection. Ultimately, he hopes this could pave the way for new therapeutic strategies in the context of inflammation, infection, and cancer.
Projects and Grants
Role of GPR35 in Granulocyte Migration and Tissue Inflammation
University of California, San Francisco | All Cancers | 2021 | Jason Cyster, Ph.D.
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