Autophagy is a cellular degradation pathway that, when it occurs in cancer cells, can impact the growth and behavior of the resulting tumor. The precise effects of stromal autophagy—as well as how they are mediated—are not well understood, though. Dr. Hillary Coller has developed a novel model that allows her to investigate how stromal autophagy affects the interactions between different cell types within the tumor environment. Specifically, she’s investigating how autophagy in the stroma might influence the response to immunotherapy. These insights could then potentially be used to develop complementary therapies that make immunotherapy more effective and improve patient survival.
University of California, Los Angeles | All Cancers, Melanoma | 2017
*Immunotherapy results may vary from patient to patient.
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Dr. E. John Wherry dicusses cell therapies and the cancer ecosystem during Day 3 of the 2022 CRI-ENCI-AACR International Cancer Immunotherapy Conference (CICON22).
Drs. Stefani Spranger and Elsa Anagnostou recap highlights relating to myeloid cells, tumor heterogeneity, and preclinical models from Day 2 of of the 2022 CRI-ENCI-AACR International Cancer Immunotherapy Conference (CICON22).