Renal cell carcinoma (RCC) accounts for 90% of all kidney cancers and is the eighth most common cancer type in the United States. While metastatic RCC has historically been considered an incurable disease despite the development of targeted therapies, immunotherapy may be able to provide more patients with better outcomes. While patients with tumors that have been infiltrated by “killer” T cells are more likely to respond to immunotherapy, however, not all of these T cells target the tumor, and so they still can’t perfectly predict who will respond or not.
Therefore, Dr. Warren aims to characterize the tumor-killing potential of the immune cells within tumors and identify patterns associated with tumor recognition as well as tumor evasion. Most importantly, he is testing the different specific T cell receptor sequences found within tumors and determine which ones are able to recognize tumor cells. Overall, the results of his studies may provide new insights into subsets of tumor-infiltrating T cells as well as help guide treatment decisions, identify new therapeutic targets, and provide the rationale for patient-specific cellular immunotherapies.
Fred Hutchinson Cancer Research Center | Kidney Cancer | 2018
*Immunotherapy results may vary from patient to patient.
Cancer Research Institute | National Headquarters
29 Broadway, Floor 4 | New York, NY 10006-3111
We are Generation Cure. On June 11, we celebrated the ninth annual global immunotherapy awareness day to support a future immune to cancer.
Cell therapy development lagged in 2020, but is gaining ground again, a new CRI report shows.