Dr. June helped pioneer breakthroughs in CAR T cell therapy, which involves genetically modifying patients’ immune cells to enhance their anti-cancer activity, for patients with blood cancers such as leukemia and lymphoma. Now, he seeks to extend the success of CAR T cells to patients with pancreatic tumors. To do so, Dr. June is using CAR T cells designed to target mesothelin, a protein commonly overexpressed in pancreatic cancer cells, which may be able to improve immune responses against these normally resistant tumors.
Projects and Grants
Mesothelin-specific chimeric antigen receptor (CAR) T cell therapy for pancreatic cancer.
University of Pennsylvania School of Medicine | Pancreatic Cancer | 2015
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