Checkpoint immunotherapies targeting the PD-1 pathway can enhance the ability of T cells to destroy tumors and have been effective in a variety of human cancers. However, these therapies are not effective in all patients with a given cancer subtype, nor in all cancers, and therefore studies interrogating the molecular basis for successful immunotherapy response are needed. To that end, Dr. Satpathy is employing novel single-cell sequencing technologies to identify the key gene regulatory mechanisms that underlie immunotherapy resistance in patients with basal cell carcinoma, which has a 30% response rate.
Additionally, he’s developing other single-cell methods to characterize the T cell receptor repertoires and epigenomes of “killer” T cells as well as using CRISPR genome editing tools to engineer T cells with enhanced capabilities against cancer. Overall, Dr. Satpathy anticipates that his findings will provde novel insights into the regulation of effective anti-tumor responses in patients and uncover new strategies for immunotherapeutic intervention.
Projects and Grants
Single-Cell Epigenome Technologies for Cancer Immunotherapy
Stanford University | All Cancers | 2020
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