Grants & Programs

CureVac

CureVac, a clinical stage biopharmaceutical company from Tübingen, Germany, is advancing the field of mRNA-based vaccination. The company uses its technology platforms for the development of novel therapeutic mRNA vaccines (RNActive®) for cancer and prophylactic vaccines for infectious diseases. Furthermore CureVac develops adjuvants based on non-coding RNAs (RNAdjuvant®) for enhancing the immune response of other vaccines. The company has successfully completed Phase I/IIa studies with its RNActive® cancer vaccines in prostate cancer and non-small cell lung cancer (NSCLC). Results so far have shown that mRNA-based products are safe and capable of inducing balanced immune responses including humoral and cellular, Th1 and Th2 and effector and memory responses. CureVac is currently running a number of clinical trials with its RNActive® vaccines, including a large randomized Phase IIb clinical trial in prostate cancer. In addition to developing its own pipeline, CureVac is collaborating with Sanofi Pasteur, In-Cell-Art and Janssen Pharmaceuticals for the development of prophylactic vaccines in infectious diseases utilizing its RNActive® technology platform.

Ludwig and CRI will conduct up to five clinical studies of cancer immunotherapy combinations through their jointly coordinated CVC Trials Network using CureVac’s investigational clinical stage drug, CV9202, combined with other priority agents available to CRI and Ludwig from their internal portfolios or accessed through additional industry partnerships. CV9202 contains NSCLC-associated antigens and is the optimized successor of CV9201, which has successfully completed a phase I/IIa clinical trial demonstrating its safety and immunogenicity. Additional investigational clinical stage drugs from CureVac’s product pipeline can be added.

For the news release, go here.