The work of William B. Coley, M.D., the father of CRI’s founder Helen Coley Nauts, was featured in the April 2004 issue of the Prevention Post, a newsletter of the National Cancer Institute’s Division of Cancer Prevention. Dr. Coley, who the article refers to as “the Sherlock Holmes of Cancer,” was a pioneer in what is now known as the field of cancer immunology. He launched a retrospective study of sarcoma patients in the late nineteenth century, which provided the impetus for the creation of Coley’s Toxins, the first cancer vaccine. The Prevention Post article provides a historical narrative of the evolution of scientific opinion towards Coley’s Toxins and Dr. Coley’s body of work from one of dismissal to current recognition and acceptance. This article, complete with a picture furnished from the CRI archives, may be viewed at: http://www3.cancer.gov/prevention/pp2004_04.pdf